Lobelia
inflata.
Lobelia,
Indian Tobacco Asthma WeedFamily: Campanulaceae
PART USED: Dried aerial parts,
collected when the lower fruits are nearly ripe. TASTE: Acrid ODOR: Slight, somewhat irritating ACTIONS GROUP: The Musculo-Skeletal System - Antispasmodics
1. Expectorant.[1,2]Respiratory stimulant.[1,2]
Antiasthmatic.[1]
2. Antispasmodic.[1,2]
3. Emetic.[1,2]
4. Bechic. INDICATONS
1. Chronic bronchitis.[1,2] Bronchitic
asthma.[1,2]Lobelia is highly regarded for the treatment of asthma,
bronchitis and as a tobacco deterrent; it is the major ingredient of many antismoking
mixtures.[2] Tonsilitis.
Croup. Diptheria. Whooping cough.
2. Ovarian or uterine pain including dysmenorrhea. During childbirth to
aid dilation and relaxation of the birth canal.
3. Muscle pain. Sprains. Rheumatic pain.
4. Angina pectoris. Circulatory imbalances.
5. Inflammations.
Topically Myositis.[1] Rheumatic nodules.[1]
Ulcers, as a poultice.[2] SPECIFIC INDICATIONS: Spasmodic asthma with secondary bronchitis.[1] COMBINATIONS
PREPARATIONS
3X /day
Dried herb 0.2-0.6 g,[1,2] or by infusion
or decoction.[1]
Ethereal Lobelia tincture (BPC1973) 0.3-1ml.[2]
Fluid extract 1:1 in 50% alcohol 0.2-0.6 ml.[1,2]
Tincture Lobelia (BPC1949) 1:8 in 60% alcohol 0.6-2 ml.[1,2]
Tincture Lobelia acid 1:10 in dilute acetic acid. 1-4 ml.[1] NOTE - The low dosage and dispense with particular care.[2] ORIGIN: Eastern USA. DESCRIPTION: An erect annual herb. Leaves; pale green or yellowish, sessile,
alternate, ovate-lanceolate, 3-8 cm long, with a toothed margin and pubescent
lamina. The fruit consists of an inflated, ovoid or flattened bilocular capsule
containing numerous small, brown, reticulate seeds. References
[1] British Herbal Pharmacopoeia 1983 Published by the British Herbal Medicine
Association ISBN 0 903032 07 4.
[2] Potter's New Cyclopaedia of Botanical Drugs and Preparations R.C.
Wren Revised by Elizabeth M. Williamson and Fred J Evans. First published
in Great Britain in 1988 and reprinted in 1989 and 1994 by the C. W. Daniel
Company Limited. 1 Church Path, Saffron Walden Essex. Published 1988 Printed
and bound by Biddles, Guildford ISBN 085207 1973. Images
1. en.wikipedia.org
by H. Zell CC BY-SA 3.0
2. Britton, N.L., and A. Brown. 1913. An illustrated flora of the northern
United States, Canada and the British Possessions. 3 Vols. Charles Scribner's
Sons, New York. Vol. 3: 303. Provided by Kentucky Native Plant Society. Scanned
by Omnitek Inc. No copyright
3. reveriefarmllc.com
4. whitecrowbotanicals.com
Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally.Harvesting
Harvest the entire above ground plant
during Winter and Spring. If drying dry in shade and the product should be stored
out of light, especially if powdered. Care should be taken by harvesters to
protect themselves from irritation to skin by excessive exposure or eyes by
the slightest exposure. Some species of Lobelia have caused contact dermatitis
by commercial harvesters.
Lobelia has been regulated in some countries.
Lobelia is undefined in the United States as a food ingredient (Leung &
Foster, 1996). However it is not included on the U.S. Food & Drug Administration
(FDA) Generally Recognized as Safe (GRAS) list (“Lobelia”, 2018).
Additionally, the FDA specifically forbids labeling lobelia products for smoking
cessation, based on insufficient evidence of efficacy and the possibility for
adverse reactions associated with the use of as little as 50 milligrams (“FDA
Warning”, 1993; “CFR Code”, 2018). Health Canada prohibits
the sale or use of lobelia by all but licensed health professionals and sets
an upper limit per single dose of 130.0 mg or 390 mg/day (“Lobelia”,
2014; “Drugs”, 2019). In Australia lobelia has been restricted to
licensed medical practitioners (Pengally, 2004).
Australian Government Federal Register of Legislation lists Lobelia inflata
as Schedule 2, "except for smoking or burning".
Piperidine alkaloids; 0.3-0.4%, lobeline,[1,2,3,4]
lobelanine,[1,2,3,4] lobelanidine.[1,2,3,4]
Minor amounts of norlobelanine, lelobanidine, lobinine, isolobinine, lobinanidine.[2,3,4]
Lobelic acid.[1,2] A neutral substance-
inflatin.[1] Resin.[5]
Gum.[5] Fats.[5] References
[1] British Herbal Pharmacopoeia 1983 Published by the British Herbal Medicine
Association ISBN 0 903032 07 4.
[2] Karawya, M. S. et al. (1971) J. Ass. Off. Ann. Chem. 54
(6), 1423
[3] Gross, D. (1971) Forts. Chem. Org. Nat. 29, 1
[4] Ayer, W. A. and Habgood, T. E. in "The alkaloids Vol. XI", Ed. R.
H. F. Manske, Pub. Academic Press (1968)
[5] Encyclopedia of Common Natural Ingredients used in Food Drugs and Cosmetics,
Albert Y. Leung. Pub. John Wiley & Sons Inc. (1980) NY
Research
Lobeline has similiar but less potent pharmacological properties to nicotine,
which helps to alleviate the withdrawal symptoms associated with stopping smoking.
Lobeline stimulated respiration in animals by stimulating the respiratory centre
and at high doses stimulated the vomiting centre. It has also been used as a poultice
for treating boils and ulcers.[1] References
[1] Potter's New Cyclopaedia of Botanical Drugs and Preparations R.C. Wren
Revised by Elizabeth M. Williamson and Fred J Evans. First published in Great
Britain in 1988 and reprinted in 1989 and 1994 by the C. W. Daniel Company Limited.
1 Church Path, Saffron Walden Essex. Published 1988 Printed and bound by Biddles,
Guildford ISBN 085207 1973. Research Lobelia-in-the-Treatment-of-Asthma-and-Respiratory-Illness.pdf
Lobeline shows protective effects against MPTP-induced dopaminergic neuron
death and attenuates behavior deficits in animals
Authors: Chao-Yue Li Li-Ming Zhao Xi-Wen Shi Jia-Dong Zhang Abstract
We previously demonstrated that lobeline effectively inhibited dopamine transporter
(DAT)-mediated dopamine (DA) transportation. Therefore, the present study aimed
to investigate whether lobeline shows protective effects against neurotoxin-induced
cell death in vivo. Mice were administered 30 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine
(MPTP) and treated with 80 mg/kg L-dopa, 10 mg/kg GBR12935 or 1 or 3 mg/kg lobeline,
respectively, via injection. Rotarod and swim tests as well as tyrosine hydroxylase
(TH) immunohistochemistry were carried out to evaluate the effects of these drugs.
Compared with L-DA and GBR12935, lobeline (3 mg/kg administered via intraperitoneal
injection) on behavior and dopaminergic neurons. Compared with L-DA and GBR12935,
lobeline (3 mg/kg injected subcutaneously) significantly reduced MPTP induced
locomotive deficits detected in behavioral tests. In addition, TH immunostaining
showed that lobeline (3 mg/kg) markedly decreased the neurotoxin-induced immunoreactivity
loss in the substantia nigra and striatum. Lobeline may be useful in the protection
of dopaminergic neurons and may alleviate the symptoms of Parkinson's disease.
Published online on: November 18, 2013 https://doi.org/10.3892/etm.2013.1413
Pages: 375-378 spandidos-publications.com
