Lepidium
apetalum.- Northern
and Northeastern China Tíng lì zǐ
Descurainia sophia.- Eastern and Southern China
Tíng lì zǐ.葶苈子 Tíng lì zǐ,
独 行 菜 Du xing cai Pepperweed
seed, Lepidium seeds, Descurainia seeds, Woods
whitlow grass Family: Cruciferae
Tíng lì zǐ is also harvested from Draba
nemorosa PART USED:Seed-
harvested in late Summer when the fruit has ripened. FLAVOR: Pungent, bitter. CHANNEL
Lung, Urinary bladder FUNCTIONS
1. Drain the Lungs, reduce phlegm, and calm wheezing.[1,2,3] Removing Heat from the Lung.
2. Promote urination,[1,2] to
reduce edema.[3] Heal swelling. INDICATIONS
1. Excess type wheeing or coughing with copius sputum and a gurgling sound in
the throat due to phlegm accumulation or Lung Heat.[3]
Phlegm accumulation and retention manifested as fullness in the chest, cough with
dyspnea and profuse sputum, inability to lie flat due to dyspnea, generalized
edema.[1,2] Asthma, chest pain, scanty
urine, heart disease.[1]
2. Facial edema or fluid accumulation in the chest or abdomen with urinary difficulty
due to excess type obstruction of the Lung and Bladder Qi.[3]
Pleural effusion, ascites, scanty urination, etc. For water retention in the intestines
shown as fullness in the abdomen, dry mouth and tongue.[2] CONTRAINDICATIONS: Wheezing and cough due to lung Qi deficiency,
and for edema due to Spleen deficiency.[3] PATENT COMBINATIONS
- Removing phlegm from the Lung- Decoction of Lepidium seed and Chinese dates
for removing phlegm from the Lung- Ting li da zao xie fei tang.[2]
- Pleural effusion with contipation and oliguria, it is often used with Bitter
apricot kernel and Rhubarb rhizome, as in Major bolus for removing Phlegm Heat
from chest- Da xian xiong wan.[2]
- Pleural effusion, ascites, scanty urination- Pleural effusion, ascites, scanty
urination. Used with Tetrandra root, Prickly ash seed, and Rhubarb rhizome,
known as Pill of Tetrandra, Prickly ash seed, Lepisium and Rhubarb- Ji jiao
li huang wan.[2]
- Cough, excessive production of sputum,
wheezing, and chest pain due to Phlegm preventing the normal descent of the
Lung Qi. Use with Ziziphus jujuba- Da zao.
- Edema of the face and fluid accumulation in the chest and abdomen, with Stephania
tetrandra- Han fang ji and Rheum tanguticum-
Da huang.
- Hardness, fullness, and pain in the chest due to stagnation. Use with Rheum
tanguticum- Da huang, and Prunus
armeniaca- Xing ren.
- Congestive heart failure, with Aconitum
carmichaeli- Fu zi and Astragalus
propinquus- Huang qi.
PREPARATIONS:Decoction
Dry ripe seed 3-10 g.[1,3] The seeds
are dried in sunlight after collection, used unprepared or stir baked slightly.[2] References
[1] A Complete English Dictionary of Medicinal
Terms in Chinese Acupuncture and Herbalism 1981- Henry Lu Chinese Foundations
of Natural Health- The Academy of Oriental Heritage, Vancouver, Canada.
[2] The Chinese Materia Medica A practical English- Chinese Library of Traditional
Chinese Medicine Publishing House of Shanghai University of Traditional Chinese
Medicine. Director Hu Ximing ISBN 7-81010-111-X/R-110.
[3] Chinese Herbal Medicine Materia Medica- Dan Bensky and Andrew Gamble- Eastland
Press 1986 Seattle Washington ISBN 0-939616-15-7 Images
1. doopedia.co.kr
2. pingguolv.com
Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally. Constituents
Descurainia; Sinapine,
benzyl isothiocyanate, allyl isothiocyanate, allyl disulfide, linolneic acid,
linoleic acid, oleic acid, erucic acid, palmitic acid, stearic acid, sitosterol,
halveticoside.[1] References
[1] Chinese Herbal Medicine Materia Medica- Dan Bensky and Andrew Gamble- Eastland
Press 1986 Seattle Washington ISBN 0-939616-15-7
Research
Inhibition of skin pigmentation by an extract of Lepidium apetalum and
its possible implication in IL-6 mediated signaling.
Choi H, Ahn S, Lee BG, Chang I, Hwang JS. Abstract
The development of effective skin-lightening agents is an increasingly important
area of research aimed at the treatment of hyperpigmentation induced by UV irradiation
or by medical conditions such as melasma, postinflammatory melanoderma and solar
lentigo. Although some inhibit tyrosinase, identifying and understanding the mechanisms
of action of other agents is an important goal if more effective pigmentation
inhibitors are to be developed. We present here that an extract of Lepidium apetalum
(ELA) decreased UV-induced skin pigmentation in brown guinea pigs and melanogenesis
of HM3KO human melanoma cells. Interestingly, ELA did not reduce melanogenesis
in HM3KO cells unless they were co-cultivated in keratinocyte-conditioned medium
prepared by culturing keratinocytes with ELA. Under these conditions, ELA decreased
tyrosinase mRNA and protein expression as well as melanin content via an ELA-mediated
increase in keratinocyte IL-6 production which in turn was shown to decrease in
the expression Mitf, a transcription factor implicated in tyrosinase gene expression
and melanocyte differentiation. The results reveal that ELA may be an effective
inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders
through a mechanism involving IL-6-mediated downregulation of Mitf rather than
a direct inhibition of tyrosinase activity.
PMID: 16280009 DOI: 10.1111/j.1600-0749.2005.00266.x Pigment Cell Res. 2005
Dec;18(6):439-46. ncbi.nlm.nih.gov
Ethanol Extract of Lepidium apetalum Seed Elicits Contractile Response
and Attenuates Atrial Natriuretic Peptide Secretion in Beating Rabbit Atria
Seung Ju Kim, Hye Yoom Kim, Yun Jung Lee, Hao Zhen Cui, Ji Yeon Jang, Dae Gill
Kang, and Ho Sub Lee Abstract
The seeds of Lepidium apetalum Willdenow (called “Tinglizi” in China and “Jungryukza”
in Korea) have been used to discharge phlegm and improve dropsy in Oriental medicine.
The present study investigated the effects of ethanol extract of the seeds of
Lepidium apetalum (ELA) on atrial dynamics and atrial natriuretic peptide (ANP)
secretion in beating rabbit atria. ELA increased atrial stroke volume, pulse pressure,
and cAMP efflux, concomitantly attenuating ANP secretion in a dose-dependent manner.
ELA-induced increases in atrial stroke volume, pulse pressure, and cAMP levels
and decrease in ANP secretion were not inhibited by pretreatment with staurosporine,
a nonspecific protein kinase inhibitor, or diltiazem and verapamil, the L-type
Ca2+ channel blockers, respectively. Helveticoside, a well-known digitalis-like
cardiac glycosidic constituent of ELA, also increased atrial dynamics, including
stroke volume and pulse pressure, without changing cAMP efflux and ANP secretion,
and the effects of helveticoside were not inhibited by pretreatment with staurosporine,
diltiazem, and verapamil. These results suggest that the ELA-induced positive
inotropic activity in beating rabbit atria might, at least partly, be due to the
digitalis-like activity of helveticoside rather than an increase in cAMP efflux.
Journal ListEvid Based Complement Alternat Medv.2013; 2013PMC3830812. Evid
Based Complement Alternat Med. 2013; 2013: 404713.
Published online 2013 Oct 29. doi: 10.1155/2013/404713
ncbi.nlm.nih.gov
Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd
Sijian Wang, Pingping Shi, Lu Qu, Jingya Ruan, Shengcai Yang, Haiyang Yu, Yi Zhang,
Tao Wang Abstract
Three new compounds, apetalumosides C₁ (1), D (2), and 1-thio--d-glucopyranosyl(1→1)-1-thio-α-d-glucopyranoside
(3), together with twenty-two known ones (4-25) were obtained from the seeds of
Lepidium apetalum Willd. Among the known isolates, 5-8, 10-13, 16-20, and 25 were
obtained from the genus for the first time; 4, 14, 15, and 21-24 were isolated
from the species for the first time. Meanwhile, the NMR data of 16 was first reported
here. Their structures were determined by means of chemical and spectroscopic
methods. On the other hand, their inhibitory effects on sodium oleate-induced
triglyceride (TG) overloading in HepG2 cells were evaluated. As a result, two
new compounds (1 and 2), together with known isolates 7-11, 13, 14, 16-18, 20,
21, and 25 possessed significant inhibitory effects in the cells.
Molecules 2017 Mar 28;22(4):540. doi: 10.3390/molecules22040540. PMID: 28350346
PMCID: PMC6154599 DOI: 10.3390/molecules22040540 pubmed.ncbi.nlm.nih.gov
Uridine derivatives from the seeds of Lepidium apetalum Willd. and their
estrogenic effects
Meng Li, Mengnan Zeng, Zhiguang Zhang, Jingke Zhang, Beibei Zhang, Xuan Zhao,
Xiaoke Zheng, Weisheng Feng
Affiliations expand
PMID: 30075391 DOI: 10.1016/j.phytochem.2018.07.013
Abstract
Ten uridine derivatives (lepidiumuridine B-K) were isolated from the seeds of
Lepidium apetalum Willd. Lepidiumuridine B-J were previously undescribed compounds,
and were structurally characterized using analysis of their NMR and MS data. Lepidiumuridine
C, D, I, and J increased cell proliferation and expression of ERα in the MCF-7
cell line. In addition, blockage of ERα completely abolished cell proliferation
and expression of ERα in MCF-7 cells, suggesting that the proliferation effects
of lepidiumuridine C, D, I, and J were ERα-mediated. The uridine derivatives might
belong to undescribed phytoestrogens.
Phytochemistry 2018 Nov;155:45-52. doi: 10.1016/j.phytochem.2018.07.013. Epub
2018 Jul 31. pubmed.ncbi.nlm.nih.gov
FLAVOR: Pungent, bitter. CHANNEL
Lung, Urinary bladder