1. Podophyllum-emodi- Himalayan MayappleSinopodophyllum hexandrum. Podophyllum emodi   Family: Berberidaceae   Himalayan Mayapple    
The genus Sinopodophyllum includes only this one species.
桃儿七  Táo ér qī   Dry root and rhizome  
Nature- slightly warm   FLAVOR: Bitter  TOXICITY: Slightly toxic
FUNCTIONS
1. Expel Wind and Dampness, benefit energy, activate blood, relieve pain and cough.[1]
INDICATIONS
1. Rheumatism, numbness, fall injuries, cough, irregular menstruation.[1]
PREPARATIONS: Dry root and rhizome 3-6 g.[1]
     
小叶莲  Xiǎo yè lián  Dry ripe fruit  
Nature- neutral   FLAVOR: Sweet, neutral   TOXICITY: Slightly toxic.[1]
FUNCTIONS
1. Regulate menstruation, activate blood.[1]
INDICATIONS
1. Dead fetus, failure in expulsion of placenta.[1]
PREPARATIONS:  Dried ripe fruit 3-9 g.[1]

References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Research

Podophyllum hexandrum (Himalayan mayapple) extract provides radioprotection by modulating the expression of proteins associated with apoptosis.
Kumar R, Singh PK, Sharma A, Prasad J, Sagar R, Singh S, Arora R, Sharma RK.
Abstract
Podophyllum hexandrum Royale (Himalayan mayapple), a high-altitude Himalayan plant, has been shown to provide over 80% whole-body radioprotection in mice. To investigate the radioprotective potential of P. hexandrum at the molecular level, expression patterns of various proteins associated with apoptosis were studied in the spleen of male Swiss albino strain A mice by immunoblotting. Treatment with P. hexandrum [200 mg/kg of body weight; an ethanolic 50% (w/v) extract delivered intraperitoneally] 2 h before irradiation resulted in MAPKAP (mitogen-activated protein kinase-activated protein) kinase-2 activation along with HSF-1 (heat-shock transcription factor-1), leading to up-regulation of HSP-70 (heat-shock protein-70) as compared with sham-irradiated (10 Gy) mice. Strong inhibition of AIF (apoptosis-inducing factor) expression was observed in the mice treated with P. hexandrum 2 h before irradiation as compared with the sham-irradiated group. Inhibition in the translocation of free NF-kappaB (nuclear factor kappaB) from cytoplasm to nucleus was observed upon P. hexandrum pretreatment 2 h before irradiation when compared with radiation-treated mice. P. hexandrum pre-treatment (2 h before irradiation) resulted in inhibition of NF-kappaB translocation, and the expression of tumour suppressor protein p53 was observed to be down-regulated as compared with sham-irradiated control. An increase in the expression of proteins responsible for cell proliferation [Bcl-2 (B-cell chronic lymphocytic lymphoma 2), Ras-GAP (Ras-GTPase-activating protein) and PCNA (proliferating cell nuclear antigen)] was observed in the P. hexandrum-pretreated irradiated mice as compared with sham-irradiated controls. Caspase 3 activation resulted PARP [poly(ADP-ribose) DNA polymerase] cleavage, and DNA degradation was strongly inhibited in the mice treated with P. hexandrm (+/-irradiation) as compared with the mice treated with radiation (+/-heat shock). The present study thus clearly demonstrated that P. hexandrum extract provides protection from gamma-radiation by the modulation of expression of proteins associated with cell death.
PMID: 15762843 DOI: 10.1042/BA20040164  Biotechnol Appl Biochem. 2005 Aug;42(Pt 1):81-92. ncbi.nlm.nih.gov

Influence of ecological factors on the production of active substances in the anti-cancer plant Sinopodophyllum hexandrum (Royle) T.S. Ying.
Liu W, Liu J, Yin D, Zhao X.
Abstract
The quality of traditional Chinese herbal medicine, which plays a very important role in the health system of China, is determined by the active substances produced by the plants. The type, content, and proportion of these substances may vary depending on ecological factors in areas where the plants are grown. Sinopodophyllum hexandrum (Royle) T.S. Ying, an endangered plant species with great medical value, was investigated in eight production locations representative of its natural geographical distribution range in China. The correlation between the contents of the active ingredients extracted from the roots and rhizomes of S. hexandrum and the ecological factors were evaluated step-by-step using a series of computational biology methodologies. The results showed that ecological factors had significant effects on the contents but not on the types of the active ingredients in eight production locations. The primary ecological factors influencing the active substances included the annual average precipitation, July mean temperature, frost-free period, sunshine duration, soil pH, soil organic matter, and rapidly available potassium in the soil. The annual average precipitation was the most important determinant factor and was significantly and negatively correlated with the active ingredient contents (P < 0.001). In contrast, organic matter was the most important limiting factor and was significantly and positively correlated with the active substances. These ecological factors caused 98.13% of the total geographical variation of the active ingredient contents. The climate factors contributed more to the active ingredient contents than did the soil factors. It was concluded that from the view of the contents of the secondary metabolites and ecological factors of each growing location, in Jingyuan, Ningxia Province, and Yongdeng, Gansu Province, conditions were favorable to the production of podophyllotoxin and lignans, whereas in Shangri-La, Yunnan Province, and Nyingchi, Tibet, conditions were favorable to the production of quercetin and kaempferol.
PMID: 25874701 PMCID: PMC4398539 DOI: 10.1371/journal.pone.0122981  PLoS One. 2015 Apr 15;10(4):e0122981. doi: 10.1371/journal.pone.0122981. eCollection 2015.   ncbi.nlm.nih.gov

A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum.
Kong Y, Xiao JJ, Meng SC, Dong XM, Ge YW, Wang RF, Shang MY, Cai SQ.
Abstract
Constituents of the fruit of Sinopodophyllum hexandrum (Royle) Ying (Sinopodophylli Fructus) were investigated. A new flavonoid, 8,2'-diprenylquercetin 3-methyl ether along with 9 known compounds were isolated and identified. Among them, the new compound 8,2'-diprenylquercetin 3-methyl ether exhibited cytotoxic activities against MDA-231 and T47D breast cancer cell lines, quercetin, kaempferol and rutin were isolated from Sinopodophylli Fructus for the first time.
Copyright 2009 Elsevier B.V. All rights reserved.
PMID: 19909799 DOI: 10.1016/j.fitote.2009.11.003 Fitoterapia. 2010 Jul;81(5):367-70. doi: 10.1016/j.fitote.2009.11.003. Epub 2009 Nov 10.  ncbi.nlm.nih.gov