Maclura
cochinchinensis. Cudrania cochinchinensis 穿破石Chuān pò shíCockspur
thorn Family: Moraceae
Is a species of vine or scrambling shrub. The native range extends from China,
through Malasia and into Queensland and northern New South Wales. The species
inhabits rainforest, but is more common in drier closed forest types, such as
monsoon forest. The globular, yellow or orange fruit are sweet and edible and
were a traditional food source for Australian Aborigines. PART USED: Root FLAVOR: Slightly bitter FUNCTIONS
1. Relieve cough, reduce jaundice, activate blood, facilitate channels.[1] INDICATIONS
1. Pulmonary tuberculosis, Damp Heat jaundice, pain in ribs, fall injuries causing
blood coagulation, rheumatic pain.[1] PREPARATIONS: Dry
root 15-30 g.[1] References
[1] A Complete English Dictionary of Medicinal Terms in Chinese Acupuncture and
Herbalism 1981- Henry Lu Chinese Foundations of Natural Health- The Academy of
Oriental Heritage, Vancouver, Canada. Images
1. ppnn.org.au Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally. Research
Antidiabetic effects of Maclura cochinchinensis pdf
Macluracochinones A-E, antimicrobial flavonoids from Maclura cochinchinensis
(Lour.) Corner
Isaraporn Polbuppha, Virayu Suthiphasilp, Tharakorn Maneerat, Rawiwan Charoensup,
Thunwadee Limtharakul, Sarot Cheenpracha, Stephen G Pyne, Surat Laphookhieo Abstract
The phytochemical investigation of the fruit and leaf extracts of Maclura cochinchinensis
(Lour.) Corner (Moraceae) resulted in the isolation and identification of four
undescribed isoflavones (macluracochinones A-D) and one undescribed flavone (macluracochinone
E), together with 24 known compounds. The structures of the undescribed compounds
were elucidated using nuclear magnetic resonance (NMR) and high-resolution electrospray
ionization time-of-flight mass spectrometry (HRESITOFMS) experiments. Gancaonin
M, lupiwighteone, lupalbigenin, warangalone, auriculatin, and millexatin F displayed
good antibacterial activities against Gram-positive bacteria with MIC values in
the range of 1-8 μg/mL. Lupalbigenin showed strong activities against methicillin-resistant
Staphylococcus aureus (MRSA) and S. aureus with the same MIC value of 1 μg/mL.
Phytochemistry 2021 Jul;187:112773. doi: 10.1016/j.phytochem.2021.112773. Epub
2021 Apr 16. PMID: 33873019 pubmed.ncbi.nlm.nih.gov
In vitro and in vivo evidence of hypouricemic and anti-inflammatory activities
of Maclura cochinchinensis (Lour.) Corner heartwood extract
Vilasinee H Sato, Savita Chewchinda, Warisara Parichatikanond, Boonyadist Vongsak Abstract
Maclura cochinchinensis (Lour.) Corner (MC) heartwood extracts have been used
for the treatment of gout, hyperuricemia, and inflammation in Thai traditional
medicine. Despite their traditional use, their mechanisms of action remain unknown.
The aim of this study was to determine the mechanisms of MC heartwood extract
activity using both in vitro and in vivo models . The extraction methods were
optimized to yield the highest contents of biochemical compounds and antioxidant
activities. The effects of MC heartwood extract on xanthine oxidase and its enzyme
kinetics were determined in vitro and the antihyperuricemic effect was evaluated
in potassium oxonate (PO)-induced hyperuricemic mice. The anti-inflammatory effect
of MC heartwood extract was also tested against lipopolysaccharide-induced proinflammatory
mRNA upregulation in RAW 264.7 mouse macrophage cells. Soxhlet extraction of MC
heartwood with 70% ethanol produced stronger antioxidant activity, and higher
total phenolic and flavonoid contents than conventional methods did (maceration
or decoction). By using HPLC, we found that MC contains morin as a major constituent,
which may account for its pharmacological activities. Moreover, administration
of MC heartwood extract (500 mg/kg) markedly decreased uric acid levels in PO-induced
hyperuricemic mice (p < 0.05). MC heartwood extract inhibited the hepatic activity
of xanthine oxidase ex vivo by approximately 53%. In addition, MC heartwood extract
markedly downregulated mRNA expression of inflammatory mediators (TNF-α, TGF-β,
iNOS, and COX-2) and this inhibition was comparable with that of dexamethasone.
Therefore, MC heartwood extract is a promising candidate as a natural treatment
for inflammation and the hyperuricemia that causes gout.
J Tradit Complement Med 2019 Mar 9;10(1):85-94. doi: 10.1016/j.jtcme.2019.03.003.
eCollection 2020 Jan. PMID: 31956562 PMCID: PMC6957808 pubmed.ncbi.nlm.nih.gov
Anti-herpes simplex virus component isolated from Maclura cochinchinensis
N Bunyapraphatsara, S Dechsree, C Yoosook, A Herunsalee, Y Panpisutchai Abstract
The powerful anti-herpes simplex virus (HSV) activity of Maclura cochinchinensis
in vitro prompted us to carry out biologically-guided separation of the active
component(s). Ethyl acetate and methanol extracts exhibited anti-HSV-2 activity
at EC50 values of 38.5 micrograms/ml and 50.8 micrograms/ml, respectively. Although
petroleum ether extract was inactive, a chloroform extract was too toxic to the
test cell culture to perform the test. Biologically-guided chromatographic separation
of the ethyl acetate extract yielded compound A, identified as morin using a spectroscopic
method. Morin exhibited anti-HSV-2 activity at an EC50 value of 53.5 micrograms/ml.
Morin pentaacetate was synthetized, but was inactive. This result suggested that
free hydroxyl groups are required for anti-HSV-activity, as demonstrated previously
for the antiviral activity of other flavonoids.
Phytomedicine 2000 Jan;6(6):421-4. doi: 10.1016/S0944-7113(00)80069-0. PMID: 10715844
pubmed.ncbi.nlm.nih.gov
FLAVOR: Slightly bitter