Hydnocarpus
anthelminticus. H. wightiana大风子Dà fēng zǐChaulmoogra Family:
Achariaceae PART USED: Oil- obtained from seeds FLAVOR: Peppery CHANNELS:
Liver, Spleen, Kidney TOXICITY: Highly toxic FUNCTIONS
1. Dries Excess Damp.[1]
2. Kills and expels worms.[1] INDICATIONS
1. Leprosy, scabies. Siphilitic ulcers.[1] PREPARATIONS:For
internal use, oil obtained from seeds 10-15 drops.[1]
A suitable amount may be used externally.[1] References
[1] Barefoot Doctor's Manual- 1977 Prepared by the Revolutionary Health Committee
of Hunan Province. Original Chinese manual- Victor W. Sidel. Originally published
by Dr Joseph Quin and the Fogarty International centre, Bethdesda (1974). Madrona
Publishers Seattle Washington ISBN 0-914842-52-8 Images
1.
blog.xuite.net
2. lvgira.narod.ru
Retrieved 7-Aug-14
Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally.
Research
Elucidating anti-aging and antioxidant activity of Hydnocarpus anthelmintica
on skin aging and cosmeceutical potentials: in silico and in vitro study
Minjee Kim, Eunji Lee, Young Bong Kim Abstract
Introduction: Hydnocarpus anthelmintica (HA) has been traditionally used for treating
leprosy and is known for its antioxidant and anti-inflammatory activities. The
aim of this study was to investigate the active compounds and targets of HA extracts,
involved in oxidative stress and skin aging. The active compounds and targets
of HA extracts were identified using network pharmacology.
Method: The pathway study was conducted using the Kyoto Encyclopedia of Genes
and Genomes (KEGG) database. HA semen was measured for its in-vitro antioxidant
activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and anti-aging activities
using collagenase, elastase, and tyrosinase assays. A total of 21 intersecting
core targets were identified from 8 compounds, 51 action targets, and 1810 skin
aging and oxidative stress-associated target genes.
Result: A compound-target network was constructed, and 3 compounds (luteolin,
beta-carotene and genkwanin), and 4 hub genes (TP53, HSP90AA1, JUN, and MAPK1)
were identified. The KEGG pathway study revealed that the compounds were correlated
with PI3K-Akt, p53, HIF-1, and MAPK signaling.
Conclusion: The results of in-vitro experiments showed the effect of HA extract
on oxidative stress reduction and collagenase inhibition. We discovered two main
active compounds, luteolin and β-carotene, that may be involved in p53 and MAPK
signaling, and showed HA extract activity against oxidative stress and collagenase.
Comb Chem High Throughput Screen . 2023 Sep 1. doi: 10.2174/1386207326666230901092247.
Online ahead of print. PMID: 37680148 pubmed.ncbi.nlm.nih.gov
FLAVOR: Peppery CHANNELS:
Liver, Spleen, Kidney TOXICITY: Highly toxic