Haematoxylum campechianum. Haematoxylon campechianum   Bloodwood, Logwood, Peachwood   Family: Leguminosae     
Haematoxylin or hematoxylin , also called natural black 1 or C.I. 75290, is a compound extracted from the heartwood of the logwood tree. Haematoxylin and eosin together make up haematoxylin and eosin stain, one of the most commonly used stains in histology. This type of stain is a permanent stain as opposed to temporary stains.
PART USED: Wood
ACTIONS
1. Astringent.[1]
INDICATIONS
1. Formerly used for diarrhea and hemorrhage.[1]
PREPARATIONS
Decoction of Logwood (BPC1934) 15-60 ml.[1]
Liquid extract (BPC1934) 2-8 ml.[1]

ORIGIN: Southern Mexico and northern Central America.
HABITAT Central America, also in West Indies.
DESCRIPTION: The wood is normally sold in chips for dyeing purposes, it has a dark, purplish-brown color with a greenish iridescece which indicated it has been fermented. For medicinal use the unfermented chips are preferred; these have a bright reddish brown tint.
References
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Constituents.
Research.

Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity.
Escobar-Ramos A, Lobato-García CE2, Zamilpa A3, Gómez-Rivera A4, Tortoriello J5, González-Cortazar M6.
Abstract
Haematoxylum campechianum is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (1); 3-deoxysappanchalcone (2); three homoisoflavonoids known as hematoxylol A (3); 4-O-methylhematoxylol (4); and, hematoxin (5). The spasmolytic activity was determined in an in vitro model (electrically induced contractions of guinea pig ileum), and allowed to demonstrate that the methanolic extract (EC50 = 62.11 ± 3.23) fractions HcF7 (EC50 = 61.75 ± 3.55) and HcF9 (EC50 = 125.5 ± 10.65) and compounds 1 (EC50 = 16.06 ± 2.15) and 2 (EC50 = 25.37 ± 3.47) of Haematoxylum campechianum present significant relaxing activity as compared to papaverine (EC50 = 20.08 ± 2.0) as a positive control.
PMID: 28837100 DOI: 10.3390/molecules22091405 Molecules. 2017 Aug 24;22(9). pii: E1405. doi: 10.3390/molecules22091405. ncbi.nlm.nih.gov

Chemical constituents from the heartwood of Haematoxylon campechianum as protein tyrosine kinase inhibitors.
Lin LG, Xie H, Wang YT, Ding J, Ye Y.
Abstract
In a previous study, we showed that a series of homoisoflavonoids from the stems of Haematoxylon campechianum possess potent protein tyrosine kinase inhibitory activity. In a further chemical investigation of the heartwood of H. campechianum, three new homoisoflavonoids, epihematoxylol B (2), 10-O-methylhematoxylol B (3), and 10-O-methylepihematoxylol B (4), were isolated and identified, together with 15 known compounds, including three homoisoflavonoids, three flavonoids, six lignans, and three unsaturated fatty acids. The structures of the new compounds were established on the basis of 1D- and 2D-NMR and other spectroscopic analyses. Using ELISA method, the new compounds and selected known compounds were tested for protein tyrosine kinase inhibitory activity targeting kinase insert domain receptor. Epihematoxylol B (2) and the known compounds, hematoxylol B (1) and hematoxylin (5), exhibited inhibitory rates of 92.22.3, 71.31.1, and 94.81.6, respectively, at 10 µM concentration.
PMID: 24827687 DOI: 10.1002/cbdv.201300183 Chem Biodivers. 2014 May;11(5):776-83. doi: 10.1002/cbdv.201300183. ncbi.nlm.nih.gov