Eucalyptus globulus and other species  Eucalyptus  Family: Myrtaceae      
Other species used for oil production include E. polybracteata, E. smithii, E. fruitictorum (Northern Victoria), E. radiata. A lemon scented Eucalyptus is obtaind from E. citriodora, which grows in Queensland.



PART USED: Mature leaves
ACTIONS
GROUP: Aromatics.
1. Antiseptic.[1,2]
2. Diaphoretic. Febrifuge.[1,2] Expectorant.[1,2]
3. Stimulant.[2]
4. Rubefacient.[1]
5. Antispasmodic.[2]
INDICATIONS
1. Catarrhal conditions.  Infections. Asthma. Croup. Sore throat.[1]
2. Leukorrhea.[1]
3. Rheumatism.[1]
4. Neuralgia.[1]
5. Wounds.[1]
6. Infections.[1]
7. Fevers of all kinds, eg. malaria, typhoid, as well as the common febrile diseases.[1]
PREPARATIONS
Decoction of fresh/dried leaves  1:50   4-5 cups daily.
Tincture  0.5-7.0 ml.
Volatile oil  0.06-0.2 ml.
Local-  Liniment 1:4 volatile oil : Olive Oil-  Rheumatism.
Lotion 1:20 volatile oil : water - wounds.
Respiratory disorders.
Inhalations and gargles.[1]

PART USED: Essential oil- of leaves and twigs.
ODOR: Characteristic.
ACTIONS- External use only.
1. Respiratory decongestant and antiseptic.[1]
2. Vulnerary. Rubifacient.[2]
INDICATIONS- External use only.
1. Cold and flu- Vapour rub as a decongestant and antiseptic.[2] Use massage blend and rub into upper back and chest. Also vaporization and steam inhalation useful.[1] A dab of 100% oil onto the pillow helps breathing at night.[1] Injested in small doses, as an ingredient of cough mixtures and lozengers, and as an inhalation.[2]
2. Gargle; 1 drop in half a glass of water for sore throats. Do not swallow.[1] Used as a flavouring for dentrifrices and in many other pharmaceuticals and cosmetics.[1]
3. Skin infections- Use in blend.[1]
4. Cold sores- Dilute and apply directly.[1]
5. Therapeutic bath for relief of symptoms of colds and flu, and to help relieve associated fevers.[1]
6. Externally as a liniment.[2]
POISONOUS - if poisoning occurs get to a doctor or hospital quickly. If swallowed do not induce vomiting. Give a glass of water.
PREPARATIONS
Eucalyptus oil: BP 0.05-0.2 ml.[2]
Massage blend.
Steam inhalation.
Vaporization- Top note.


ORIGIN: Victoria and Tasmania in Australia, cultivated in Southern Europe and elsewhere.
DESCRIPTION: The leaves are scimitar-shaped, 10-15 cm long and about 3 cm wide, shortly stalked and rounded at the base, with numberous transparent oil glands.
References

Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.

Similar plants

Constituents

Constituents.
Volatile oil, up to about 3.5%, the major component of which is 1,8 cineol, 70-85%; with terpineole, a-pinene, p-cymene and small amounts of sesquiterpenes such as ledol, aroma-dendrene and viridoflorol; aldhydes, ketones and alcohols.[1,2,3]
Polyphenolic acids; caffeic, ferulic , gallic, protocatechuic.[4]
Flavonoids inlcuding eucalyptin, hyperoside and rutin.[4]
Resin. Tannin.
References
[1] Ikeda, R. M. et al. (1962) J. Food. Sci. 27, 455
[2] Frenaroli's Handbook of Flavor Ingredients, Vol. 1. 2nd Ed. Pub. CRC Press (1975)
[3] Encyclopedia of Common Natural Ingredents used in Food Drugs and Cosmetics, Albert Y. Leung. Pub. John Wiley & Sons Inc. (1980) NY
[4] Boukef, K. et al. (1976) Plant. Med. Phytother. 10, 24, 30, 119
Research

Immune-modifying and antimicrobial effects of Eucalyptus oil and simple inhalation devices.
Sadlon AE, Lamson DW.
Abstract
Eucalyptus oil (EO) and its major component, 1,8-cineole, have antimicrobial effects against many bacteria, including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA), viruses, and fungi (including Candida). Surprisingly for an antimicrobial substance, there are also immune-stimulatory, anti-inflammatory, antioxidant, analgesic, and spasmolytic effects. Of the white blood cells, monocytes and macrophages are most affected, especially with increased phagocytic activity. Application by either vapor inhalation or oral route provides benefit for both purulent and non-purulent respiratory problems, such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD). There is a long history of folk usage with a good safety record. More recently, the biochemical details behind these effects have been clarified. Although other plant oils may be more microbiologically active, the safety of moderate doses of EO and its broad-spectrum antimicrobial action make it an attractive alternative to pharmaceuticals. EO has also been shown to offset the myelotoxicity of one chemotherapy agent. Whether this is a general attribute that does not decrease the benefit of chemotherapy remains to be determined. This article also provides instruction on how to assemble inexpensive devices for vapor inhalation.
PMID: 20359267 Altern Med Rev. 2010 Apr;15(1):33-47. ncbi.nlm.nih.gov

Effect of Eucalyptus Oil Inhalation on Pain and Inflammatory Responses after Total Knee Replacement: A Randomized Clinical Trial
Yang Suk Jun, Purum Kang, Sun Seek Min, Jeong-Min Lee, Hyo-Keun Kim, and Geun Hee Seol ,*
Abstract
Eucalyptus oil has been reported effective in reducing pain, swelling, and inflammation. This study aimed to investigate the effects of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement (TKR) surgery. Participants were randomized 1?:?1 to intervention group (eucalyptus inhalation group) or control group (almond oil inhalation group). Patients inhaled eucalyptus or almond oil for 30 min of continuous passive motion (CPM) on 3 consecutive days. Pain on a visual analog scale (VAS), blood pressure, heart rate, C-reactive protein (CRP) concentration, and white blood cell (WBC) count were measured before and after inhalation. Pain VAS on all three days (P < .001) and systolic (P < .05) and diastolic (P = .03) blood pressure on the second day were significantly lower in the group inhaling eucalyptus than that inhaling almond oil. Heart rate, CRP, and WBC, however, did not differ significantly in the two groups. In conclusion, inhalation of eucalyptus oil was effective in decreasing patient's pain and blood pressure following TKR, suggesting that eucalyptus oil inhalation may be a nursing intervention for the relief of pain after TKR.
Evid Based Complement Alternat Med. 2013; 2013: 502727.
Published online 2013 Jun 18. doi: 10.1155/2013/502727
PMCID: PMC3703330 Evid Based Complement Alternat Med. 2013; 2013: 502727.
Published online 2013 Jun 18. doi: 10.1155/2013/502727
PMCID: PMC3703330 PMID: 23853660 PMID: 23853660 ncbi.nlm.nih.gov
 
Stimulatory effect of Eucalyptus essential oil on innate cell-mediated immune response
Annalucia Serafino,corresponding author Paola Sinibaldi Vallebona, Federica Andreola, Manuela Zonfrillo, Luana Mercuri, Memmo Federici, Guido Rasi, Enrico Garaci, and Pasquale Pierimarchi
Abstract
Background
Besides few data concerning the antiseptic properties against a range of microbial agents and the anti-inflammatory potential both in vitro and in vivo, little is known about the influence of Eucalyptus oil (EO) extract on the monocytic/macrophagic system, one of the primary cellular effectors of the immune response against pathogen attacks. The activities of this natural extract have mainly been recognized through clinical experience, but there have been relatively little scientific studies on its biological actions. Here we investigated whether EO extract is able to affect the phagocytic ability of human monocyte derived macrophages (MDMs) in vitro and of rat peripheral blood monocytes/granulocytes in vivo in absence or in presence of immuno-suppression induced by the chemotherapeutic agent 5-fluorouracil (5-FU).
Methods
Morphological activation of human MDMs was analysed by scanning electron microscopy. Phagocytic activity was tested: i) in vitro in EO treated and untreated MDMs, by confocal microscopy after fluorescent beads administration; ii) in vivo in monocytes/granulocytes from peripheral blood of immuno-competent or 5-FU immuno-suppressed rats, after EO oral administration, by flow cytometry using fluorescein-labelled E. coli. Cytokine release by MDMs was determined using the BD Cytometric Bead Array human Th1/Th2 cytokine kit.
Results
EO is able to induce activation of MDMs, dramatically stimulating their phagocytic response. EO-stimulated internalization is coupled to low release of pro-inflammatory cytokines and requires integrity of the microtubule network, suggesting that EO may act by means of complement receptor-mediated phagocytosis. Implementation of innate cell-mediated immune response was also observed in vivo after EO administration, mainly involving the peripheral blood monocytes/granulocytes. The 5-FU/EO combined treatment inhibited the 5-FU induced myelotoxicity and raised the phagocytic activity of the granulocytic/monocytic system, significantly decreased by the chemotherapic.
Conclusion
Our data, demonstrating that Eucalyptus oil extract is able to implement the innate cell-mediated immune response, provide scientific support for an additional use of this plant extract, besides those concerning its antiseptic and anti-inflammatory properties and stimulate further investigations also using single components of this essential oil. This might drive development of a possible new family of immuno-regulatory agents, useful as adjuvant in immuno-suppressive pathologies, in infectious disease and after tumour chemotherapy.
BMC Immunol. 2008; 9: 17.
Published online 2008 Apr 18. doi: 10.1186/1471-2172-9-17
PMCID: PMC2374764 PMID: 18423004  ncbi.nlm.nih.gov
 
The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage.
Dörsam B, Wu CF, Efferth T, Kaina B, Fahrer J.
Abstract
The natural compound 1,8-cineol, also known as eucalyptol, is a major constituent of eucalyptus oil. This epoxy-monoterpene is used as flavor and fragrance in consumer goods as well as medical therapies. Due to its anti-inflammatory properties, 1,8-cineol is also applied to treat upper and lower airway diseases. Despite its widespread use, only little is known about the genotoxicity of 1,8-cineol in mammalian cells. This study investigates the genotoxicity and cytotoxicity of 1,8-cineol in human and hamster cells. First, we observed a significant and concentration-dependent increase in oxidative DNA damage in human colon cancer cells, as detected by the Formamidopyrimidine-DNA glycosylase (Fpg)-modified alkaline comet assay. Pre-treatment of cells with the antioxidant N-acetylcysteine prevented the formation of Fpg-sensitive sites after 1,8-cineol treatment, supporting the notion that 1,8-cineol induces oxidative DNA damage. In the dose range of DNA damage induction, 1,8-cineol did neither reduce the viability of colon cancer cells nor affected their cell cycle distribution, suggesting that cells tolerate 1,8-cineol-induced oxidative DNA damage by engaging DNA repair. To test this hypothesis, hamster cell lines with defects in BRCA2 and Rad51, which are essentials players of homologous recombination (HR)-mediated repair, were treated with 1,8-cineol. The monoterpene induced oxidative DNA damage and subsequent DNA double-strand breaks in the hamster cell lines tested. Intriguingly, we detected a significant concentration-dependent decrease in viability of the HR-defective cells, whereas the corresponding wild-type cell lines with functional HR were not affected. Based on these findings, we conclude that 1,8-cineol is weakly genotoxic, inducing primarily oxidative DNA damage, which is most likely tolerated in DNA repair proficient cells without resulting in cell cycle arrest and cell death. However, cells with deficiency in HR were compromised after 1,8-cineol treatment, suggesting a protective role of HR in response to high doses of 1,8-cineol.
PMID: 24912782 DOI: 10.1007/s00204-014-1281-z Arch Toxicol. 2015 May;89(5):797-805. doi: 10.1007/s00204-014-1281-z. Epub 2014 Jun 10. ncbi.nlm.nih.gov

Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus
Raho G Bachir,* and M Benali
Abstract
Objective
To examine the in vitro antimicrobial activities of essential oil of the leaves of Eucalyptus globulus (E. globulus).
Methods
The essential oils of this plant were obtained by the hydrodistillation method. The inhibitory effects of this essential oil were tested against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by using agar disc diffusion and dilution broth methods.
Results
The results obtained showed that essential oil of the leaves of E. globulus has antimicrobial activity against gram negative bacteria (E. coli) as well as gram positive bacteria (S. aureus).
Conclusion
The encouraging results indicate the essential oil of E. globulus leaves might be exploited as natural antibiotic for the treatment of several infectious diseases caused by these two germs, and could be useful in understanding the relations between traditional cures and current medicines.
Asian Pac J Trop Biomed. 2012 Sep; 2(9): 739–742.
doi: 10.1016/S2221-1691(12)60220-2
PMCID: PMC3609378 PMID: 23570005 ncbi.nlm.nih.gov