[1] A Complete English Dictionary of Medicinal Terms in Chinese Acupuncture and
Herbalism 1981- Henry Lu Chinese Foundations of Natural Health- The Academy of
Oriental Heritage, Vancouver, Canada. Images
1. blog.zaq.ne.jp
Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally. Research
Acyclic monoterpenoid-rich essential oil of Cymbopogon distans mitigates
skin inflammation: a chemico-pharmacological study
Divya Bhatt, Swati Singh, Munmun Kumar Singh, Anil Kumar Maurya, Amit Chauhan,
Rajendra Chandra Padalia, Ram Swaroop Verma, Dnyaneshwar U Bawankule Abstract
The topical application of essential oils is considered an effective treatment
for skin diseases. Cymbopogon distans (Nees ex Steud.) Wats (Poaceae) is a promising
aromatic grass widespread in the Himalayan temperate zone. Therefore, using in-vitro
and in-vivo bioassays, we examined the chemical and pharmacological characteristics
of essential oil hydro-distilled from C. distans coded as CDA-01, specifically
concerning skin inflammation. Characterization using GC-FID and GC-MS provided
a chemical fingerprint for CDA-01, enabling the identification of 54 compounds;
amongst them, citral (34.3%), geranyl acetate (21.2%), and geraniol (16.4%) were
the most abundant. To examine the anti-inflammatory potential, CDA-01 treatment
on LPS-stimulated macrophage cells in addition to 12-O-tetradecanoylphorbol-13-acetate
(TPA) generated cutaneous inflammatory reaction in the mouse ear was assessed
through quantification of the inflammatory markers. Consequently, CDA-01 demonstrated
protection against inflammation caused by LPS by lowering the pro-inflammatory
cytokines (IL-6 and TNF-α) level in HaCaT cells with negligible cytotoxicity.
Consistent with the in-vitro findings, CDA-01 treatment reduced pro-inflammatory
mediators (TNF-, IL-6, and NO) and lipid peroxidation in an in-vivo investigation.
Subcutaneous inflammation in TPA-treated mice ears was similarly decreased, as
evidenced by the histological and morphological studies. As a result of our findings,
it is possible that CDA-01 could be an effective treatment for skin inflammation
disorders.
Inflammopharmacology . 2023 Aug 5. doi: 10.1007/s10787-023-01302-0. Online ahead
of print. PMID: 37541972 pubmed.ncbi.nlm.nih.gov