Alstonia constricta. Fever bark, Bitter bark, Australian quinine Family: Apocynaceae  
PART USED: Stem bark
GROUP: Tonics
TASTE: Bitter
ACTIONS
1. Febrifuge.[1,5] Tonic.[1,5]
2. Spasmolytic.[1] Antihypertensive.[1]
3. Uterine stimulant.[3]
INDICATIONS
1. Fevers.[1]
CONTRAINDICATIONS: This herb has been shown to be a uterine stimulant-thought to be due to the reserpine content-[4] and should therefore be avoided in pregnancy.[3]
PREPARATIONS: 0.1-5 g.[1] The latex or milky sap has been used for infectous sores. Care should be exercised, however, since it is very severe to the skin.[9]
Liquid extract 4-40 drops 0.3-3 ml.[1]
Tincture 1 to 8 1-4 ml.[1] Tincture by extraction of 100 g of bark with 750 ml of proof spirit; five to ten drops is the usual dose.[6,7,8]
Infusion 15-30 ml.[1]
Pills from powdered bark and liquorice.
HABITAT: Prefers sandy and loamy soiols; sometimes on rocky outcrops. Also in rainforest clearings, in open scrub and on alluvial snad ridges along watercourses.
ORIGIN: Native to India. In central and southern Queensland; also on the far North Coast, NorthWest slopes and NorthWest plains in New South Wales.
DESCRIPTION: A shrub or tree up to 12 m high, sometimes in dense thickets growing from root suckers. Its yellowish grey outer bark is thick, corky, and deeply fissured. The inner bark is yellow, somewhat fibrous, and intensely bitter to the taste. Its leaves are opposite, soft, bright green, slightly glossy on the upper side and usually duller and paler on the underside owing to a dense coating of short hair. They are narrow and taper at both ends, about 7.5-12.5 cm long and 1.5-2.5 cm side. The leaf stalk exudes a milky sap when cut or bruised. Flowers are creamy white, star-shaped and about 4 mm across. They occur in open bunches either at the end of branches or in the forks of the upper leaves. The fruit consist of pairs of long narrow pods.
A. constrica bark occurs in quilled pices, it has a thick brown cork and is deeply fissured. The inner surface is yellowish-brown and coarsely striated, facture fibrous.
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Constituents
Research
Is has been said to be a better antiperiodic than quinine or cinchonidine, and a cerebro-spinal stimulant, particularly during influenza and early stage of typhoid fever. It has little antimalarial activity.[1]
References
[1] Potter's New Cyclopaedia of Botanical Drugs and Preparations  R.C. Wren Revised by Elizabeth M. Williamson and Fred J Evans. First published in Great Britain in 1988 and reprinted in 1989 and 1994 by the C. W. Daniel Company Limited. 1 Church Path, Saffron Walden Essex. Published 1988 Printed and bound by Biddles, Guildford ISBN 085207 1973.

Alstonia alkaloids- Alstoniline by W. Lincoln Hawkins and Robert C. Elderfield
J. Org. Chem. 1942, 07, 6, 573–580 Publication Date:November 1, 1942 pubs.acs.org