Agastache rugosa.- Korean mint  藿 香 Huò xiāng     Family: Labiatae  
Pogostemon cablin.- Patchouli 广 藿 香Guǎnɡ huò xiānɡ Family: Lamiaceae
PART USED: Stems and Leaves- harvested mid Summer when the plant grows vigorously.
Nature: Warm        FLAVOR: Pleasant, yet acrid  CHANNELS: Stomach and Spleen, Lung
ACTIONS
GROUP- Aromatic Damp Resolving
1. Aromatically tansforms Dampness.[3] Strengthens the Stomach.[1,2] Stops vomiting.[1,2] Stops diarrhea.[2] Resolves moisture.[1]
2. Harmonizes the middle Burner and stops vomiting.[3]
3. Releases the exterior and transforms turbidity.[3] Clears fevers.[1,2]
4. Clears Wind Cold, with a Warm Nature.[2]
INDICATIONS
1. Turbid Dampness creating internal obstruction.[3] Dampness obstructing the middle Burner and interfering with the Spleens transportive functions.[3] Summer Damp.[1] Heat stroke- Summer Heat Damp-[2] nausea, thirst vomiting. Abdominal distension and fullness, nausea, vomiting, reduced apetite, white moist tongue coating.[3]
2. Vomiting and diarrhea caused by Phlegm, and other types of vomiting when combined with appropriate herbs.[1,3] Acute gastritis-[2] Flatulence, pains in upper abdomen, fever, tiredness, vomiting and abdominal pain, bad breath. T- sticky coat P-soft and retarded. .Morning sickness.[3]
3. Damp Warm febrile diseases or Summer Heat as well as externally contracted Wind Cold with internal injury from Dampness.[3] In addition to the exterior signs, these patients have digestive symptoms such as nausea, abdominal distention, or stomachache.[3]
4. Angina pains.[1]
5. Wound injuries.[1]
CONTRAINDICATIONS: Deficient Heat, Vomiting caused by Stomach Heat P- flooding- Hot Yang Ming.[2] Yin deficiency with Heat signs, and Stomach fire.[3]
PATENT COMBINATIONS
COMBINATIONS
PREPARATIONS: Mixed with boiled water or in decoction 6-9 g.[1] 6-15 g.[2] 4.5-9 g.[3] Do not cook fore more than 15 minutes. Good quality Agastache has many leaves, blue-green stems and branches, and is aromatic. Good quality Pogostemon has a coarse stem, soft and thick leaves, and is green and aromatic. In general Pogostemon is considered to be of better quality.[3

HABITAT: Grows wild on hillsides, stream bands or cultivated in gardens.
DESCRIPTION
References
 Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Similar plants
Constituents
Research

Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review pdf

HIV integrase inhibitory activity of Agastache rugosa.
Kim HK, Lee HK, Shin CG, Huh H.
Abstract
We have been screening anti-HIV integrase compounds from Korean medicinal plants by using an in vitro assay system which is mainly composed of recombinant human immunodeficiency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots of Agastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The IC50 of the rosmarinic acid was approximately 10 microg/ml against HIV integrase.
PMID: 10549582  Arch Pharm Res. 1999 Oct;22(5):520-3. ncbi.nlm.nih.gov

Antimicrobial, antibiofilm and antitumor activities of essential oil of Agastache rugosa from Xinjiang, China.
Haiyan G, Lijuan H, Shaoyu L, Chen Z, Ashraf MA.
Abstract
In the study, we evaluated chemical composition and antimicrobial, antibiofilm, and antitumor activities of essential oils from dried leaf essential oil of leaf and flower of Agastache rugosa for the first time. Essential oil of leaf and flower was evaluated with GC and GC-MS methods, and the essential oil of flower revealed the presence of 21 components, whose major compounds were pulegone (34.1%), estragole (29.5%), and p-Menthan-3-one (19.2%). 26 components from essential oil of leaf were identified, the major compounds were p-Menthan-3-one (48.8%) and estragole (20.8%). At the same time, essential oil of leaf, there is a very effective antimicrobial activity with MIC ranging from 9.4 to 42 μg ml(-1) and potential antibiofilm, antitumor activities for essential oils of flower and leaf essential oil of leaf. The study highlighted the diversity in two different parts of A. rugosa grown in Xinjiang region and other places, which have different active constituents. Our results showed that this native plant may be a good candidate for further biological and pharmacological investigations.
PMID: 27298587 PMCID: PMC4890188 DOI: 10.1016/j.sjbs.2016.02.020  Saudi J Biol Sci. 2016 Jul;23(4):524-30. doi: 10.1016/j.sjbs.2016.02.020. Epub 2016 Mar 19. ncbi.nlm.nih.gov

Attenuating properties of Agastache rugosa leaf extract against ultraviolet-B-induced photoaging via up-regulating glutathione and superoxide dismutase in a human keratinocyte cell line.
Oh Y, Lim HW, Huang YH, Kwon HS, Jin CD, Kim K, Lim CJ.
Abstract
Agastache rugosa Kuntze, known as a Korean mint, is an herbal medicine that has been used for the treatment of diverse kinds of symptoms in traditional medicine. This work was undertaken to assess the protective properties of A. rugosa leaves against UV-B-induced photoaging in HaCaT keratinocytes. They were evaluated via analyzing reactive oxygen species (ROS), promatrix metalloproteinase-2 (proMMP-2) and -9 (proMMP-9), total glutathione (GSH), total superoxide dismutase (SOD), cellular viability, flavonoid content and in vitro radical scavenging activity. Total flavonoid content of ARE, a hot water extract of A. rugosa leaves, was 22.8±7.6mg of naringin equivalent/g ARE. ARE exhibited ABTS(+) radical scavenging activity with an SC50 of 836.9μg/mL. ARE attenuated the UV-B-induced ROS generation. It diminished the UV-B-induced elevation of proMMP-2 and -9 at both activity and protein levels. On the contrary, ARE was able to enhance the UV-B-reduced total GSH and total SOD activity levels. ARE, at the used concentrations, was unable to interfere with the cellular viabilities of HaCaT keratinocytes under UV-B irradiation. Taken together, ARE possesses a protective potential against UV-B-induced photoaging in HaCaT keratinocytes, possibly based upon up-regulating antioxidant components, including total GSH and SOD. These findings reasonably suggest the use of A. rugosa leaves as a photoprotective resource in manufacturing functional cosmetics.
PMID: 27579986 DOI: 10.1016/j.jphotobiol.2016.08.026  J Photochem Photobiol B. 2016 Oct;163:170-6. doi: 10.1016/j.jphotobiol.2016.08.026. Epub 2016 Aug 23. ncbi.nlm.nih.gov

Essential oil compounds from Agastache rugosa as antifungal agents against Trichophyton species.
Shin S.
Abstract
The antifungal activities of the essential oil from Agastache rugosa and its main component, estragole, combined with ketoconazole, one of the azole antibiotics commonly used to treat infections caused by Trichophyton species, were evaluated in this study. The combined effects were measured by the checkerboard microtiter and the disk diffusion tests, against T. erinacei, T. mentagrophytes, T. rubrum, T. schoenleinii and T. soudanense. Susceptibility of the five Trichophyton species to the oil alone, or ketoconazole alone, differed distinctly. The fractional inhibitory concentration indices (FICI) of ketoconazole combined with estragole or A. rugosa essential oil, against the tested Trichophyton species, were between 0.05 and 0.27, indicating synergistic effects. These drug combinations exhibited the most significant synergism against T. mentagrophytes, with FICIs of 0.05 and 0.09 for estragole and the essential oil fraction from A. rugosa, respectively. Isobolograms based on the data from checkerboard titer tests also indicated significant synergism between ketoconazole and the Agastache oil fraction or estragole, against the Trichophyton species evaluated. Trichophyton susceptibility to ketoconazole was significantly improved by combination with the Agastache rugosa oil fraction or its main component, estragole.
PMID: 15089034  Arch Pharm Res. 2004 Mar;27(3):295-9. ncbi.nlm.nih.gov

Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-α and IL-1β
Hwa Min OhYoung Jin KangSun Hee KimYoung Soo LeeMin Kyu ParkJa Myung HeoJin ji SunHyo Jung KimEun Sil KangHye Jung KimHan Geuk SeoJae Heun LeeHye Sook Yun-ChoiKi Churl Chang
Abstract
It has been suggested that nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) may act as a mediator of cytokine-induced effects on bone turn-over. NO is also recognized as an important factor in bone remodeling, i.e., participating in osteoblast apoptosis in an arthritic joint. The components ofAgastache rugosa are known to have many pharmacological activities. In the present study, we investigated the effects of Agastache rugosa leaf extract (ELAR) on NO production and the iNOS expression in ROS 17/2.8 cells activated by a mixture of inflammatory cytokines including TNF-α and lL-1². A preincubation with ELAR significantly and concentration-dependently reduced the expression of iNOS protein in ROS 17/2.8 cells activated with the cytokine mixture. Consequently, the NO production was also significantly reduced by ELAR with an IC50 of 0.75 mg/mL The inhibitory mechanism of iNOS induction by ELAR prevented the activation and translocation of NF-κB (p65) to the nucleus from the cytosol fraction. Furthermore, ELAR concentration-dependently reduced the cellular toxicity induced by sodium nitroprusside, an NO-donor. These results suggest that ELAR may be beneficial in NO-mediated inflammatory conditions such as osteoporosis.
Archives of Pharmacal Research March 2005, Volume 28, Issue 3, pp 305–310 link.springer.com