Geijera parviflora. Geijera pendula Australian willow, Wilga, Sheep bush, Gingerah  Family: Rutaceae     
PART USED: Leaves
ACTIONS
GROUP: Analgesic.[1]
1. Alleviate pain, using an infusion of the leaves used internally and exernally.[2]
2. Chewed leaves were place into acities to stop toothache.[2]
ORIGIN: Dry inland Australia, in all states except Tasmania.
DESCRIPTION: A small tree, 6-9 m high and up to 30 cm in diameter. Its dense dark green crown of pendulous branches, brearing alternate long (7-15 cm) and narrow (about 5 mm) leaves gives the tree a willow-like appearance and makes it a valuable shade tree. Its bark is rough aned dark- colored near the butt and smooth and lighter colored on the upper part and branches. It flowers in spring. The small flower are arranged in open terminal clusters. The fruits are small, black, globular berries with a weak peppery taste.
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Constituents
Chemically very variable. A form eaten by sheep contains the coumarin geiparvarin, wheras a form rejected by sheep contains another coumarin, dehydrogeijerin.[1]
The volatile oils present in the foliage are equally variable in their composition. Some are rich in the monterpenoid alcohol linalool, others in phloracetophenone dimethyl ether.[1]
References
Research

Compounds from Geijera parviflora with prostaglandin E2 inhibitory activity may explain its traditional use for pain relief.
Banbury LK, Shou Q, Renshaw DE, Lambley EH, Griesser HJ, Mon H, Wohlmuth H.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
Australian Aboriginal people used crushed leaves of Geijera parviflora Lindl. both internally and externally for pain relief, including for toothache (Cribb and Cribb, 1981). This study tested the hypothesis that this traditional use might be at least in part explained by the presence of compounds with anti-inflammatory activity.
MATERIALS AND METHODS:
A crude extract (95% EtOH) was prepared from powdered dried leaves. From the CH3Cl fraction of this extract compounds were isolated by bioassay-guided fractionation and tested for: (1) cytotoxicity in RAW 264.7 murine leukemic monocyte-macrophages, (2) prostaglandin E2 (PGE2) inhibitory activity in 3T3 Swiss albino mouse embryonic fibroblast cells, as well as (3) nitric oxide (NO) and (4) tumour necrosis factor alpha (TNFa) inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Isolated compounds were also tested for (5) antibacterial activity against a panel of Gram-positive (Staphylococcus aureus ATCC 29213 and ATCC 25923, Staphylococcus epidermidis ATCC 35984, biofilm-forming) and Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) strains by broth microdilution.
RESULTS:
Eleven compounds were isolated, including one new flavone and one new natural product, with a further four compounds reported from this species for the first time. Some of the compounds showed good anti-inflammatory activity in vitro. In particular, flindersine (1) and N-(acetoxymethyl) flindersine (3) inhibited PGE2 release with IC50 values of 5.0µM and 4.9µM, respectively, without any significant cytotoxicity. Several other compounds showed moderate inhibition of NO (5, 6, 7) and TNF-a (6), with IC50 in the low micromolar range; however much of this apparent activity could be accounted for by the cytotoxicity of these compounds. None of the compounds showed anti-bacterial activity.
CONCLUSIONS:
The inhibition of PGE2, an important mediator of inflammation and pain, by flindersine and a derivative thereof, along with the moderate anti-inflammatory activity shown by several other compounds isolated from Geijera parviflora leaf extract, support the traditional use of this plant for pain relief by Australian Aboriginal people.
PMID: 25656002 DOI: 10.1016/j.jep.2015.01.033  J Ethnopharmacol. 2015 Apr 2;163:251-5. doi: 10.1016/j.jep.2015.01.033. Epub 2015 Feb 2. ncbi.nlm.nih.gov

Chemogeography and antimicrobial activity of essential oils from Geijera parviflora and Geijera salicifolia (Rutaceae): two traditional Australian medicinal plants.
Sadgrove NJ, Gonçalves-Martins M, Jones GL.
Abstract
Essential oils were hydrodistilled from 27 specimens of Geijera parviflora Lindl., (Rutaceae) and nine specimens of Geijera salicifolia Schott, collected over a wide geographic range in New South Wales, Queensland and South Australia. Essential oils were produced by traditional hydrodistillation and characterised using GC-MS. From one specimen a serendipitous discovery was made of bioactive coumarins dissolved in the hydrosol, which were the coumarins isopsoralen, xanthyletine and osthole. These coumarins were not present in the essential oil from that specimen. Using essential oil composition from all specimens, principal component analysis (PCA) demonstrated nine clusters for G. parviflora and three for G. salicifolia. Some clusters are representative of previously described chemotypes and some are reflective of possible chemotypes requiring more comprehensive sampling for confirmation. Thus, another three or four possible chemotypes of G. parviflora and one of G. salicifolia have been tentatively identified. Using micro-titre plate broth dilution assays, antibacterial and antifungal activity of all chemotypes was investigated. In this regard, the 'green oil' chemotype, restricted to G. parviflora, with major components linalool, geijerene/pregeijerene, 1,8-cineol and bicyclogermacrene, demonstrated the highest antimicrobial and free radical scavenging activity. Thus, in the light of traditional use reports of local analgaesia and bioactivity demonstrated in the current study, oils from select chemotypes of G. parviflora may be useful in suitably compounded lotions and creams designed for topical antimicrobial applications and local pain relief. In addition, because major components are known for insecticidal activities, such lotions may also be useful as topically applied insect repellents.
PMID: 24878365 DOI: 10.1016/j.phytochem.2014.05.004  Phytochemistry. 2014 Aug;104:60-71. doi: 10.1016/j.phytochem.2014.05.004. Epub 2014 May 27. ncbi.nlm.nih.gov