Apium graveolens var. dulce   Celery   Family Umbelliferae        
There is also a wild variety- this extract is concerned with the cultivated variety. dulce
PART USED:  Seeds. Stem is used extensively as edible vegetable.
TASTE: Aromatic, charactoristic. Slightly camphoraceous   ODOR: Aromatic.
ACTIONS
GROUP:  The Musculo-Skeletal System- Antirheumatics
1. Diuretic.[3] Urinary antiseptic.[1]
2 . Antiinflammatory.[3] Antirheumatic.[1,3] Alterative.[5]
3 . Stomachic. Digestive.[5]
4 . Hypotensive.[3]
5. Sedative.[1] Carminative.[3] Cooling.[5]
6. Tonic.[3,5] Aphrodisiac.[3]
INDICATIONS
1. Rheumatism.[1] Arthritis.[1] Gout.[1]
2. Inflammation of the urinary tract.[1]
3. Menstrual fluxes.[5]
4. Digestive troubles of children.[5]
SPECIFIC INDICATION: Rheumatoid arthritis with mental depression.[1]
CONTRAINDICATIONS: Medicinal doses of celery seed may stimulate uterine contractions and should not be used during pregnancy.[1]
COMBINATIONS
- Rheumatic disease- use with Menyanthes trifoliata- Bogbean and /or Guaiacum.
- Dandelion appears to reinforce action of Celery.
PREPARATIONS:  3X /day The express juice of the bleached stalk is the form much use medicinally.[5]
Powdered seeds 1-4 g.[3]
Dried fruits  0.5-2 g,[1] or by decoction 1:5.[1]. 1:10
Fluid extracts   a)  1:1 in 60% alcohol[4] (BPC1934)  0.3-1.2 ml.[1] 0.3-1.5 ml.[3]
  b)  1:1 in 90% alcohol   0.3-1.2 ml.[1]
Essential oil 0.05-0.1 ml.[3]

ORIGIN: England. Cultivated widely, in temperate regions.
DESCRIPTION: A strongly smelling erect biennial herb, 30-60 cm tall. Leaves; pinnate, shiny, with large toothed leaflets, the upper trifoliate and unstalked. Flowers; white, in sessile or shortly stalked umbels often opposite the leaves.
References
Constituents
Research
The aqueous extract has been shown to reduce adjuvant-induced arthritis in rats,[1] and to be hypotensive in patients as well as animals.[2,3]
The phthalides are sedative in mice,[4] and exhibit anti-epileptic acitivity in rats and mice.[5]
The volatile oil has antifungal activity.[3]
Clinical studies in China have confirmed the usefulness of the tincture in cases of hypertension of various types; the drop in blood pressure is accompanied by an increased urine output and an amelioration of subjective symptoms such as an improvement in sleep patterns.[3]
Drug Interactions- May increase diuresis.
References

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities.
Powanda MC, Whitehouse MW, Rainsford KD.
Abstract
Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.
PMID: 26462366 Prog Drug Res. 2015;70:133-53. ncbi.nlm.nih.gov

Effects of aqueous extract of celery (Apium graveolens L.) leaves on spermatogenesis in healthy male rats.
Hardani A, Afzalzadeh MR, Amirzargar A, Mansouri E, Meamar Z.
Abstract
OBJECTIVES:
Nowadays, a lot of attention has been paid to the therapeutic properties of herbs, including evaluation of the effects of these plants on fertility in laboratory animals. Apium graveolens L. (celery) has been widely used in traditional medicine for treatment of various disorders including impotency. Therefore, this study was designed to investigate the effects of aqueous extract of A. graveolens on testicular tissue and spermatogenesis in healthy male rats.
MATERIALS AND METHODS:
In this research, 24 apparently healthy male rats were divided into three groups, including eight rats in each. The first group as control received only distilled water 1 ml/animal/day. The second and third groups orally received 100 and 200 mg/kg b.w. of the extract, respectively, for 30 days. The day after the last administration of the extract, the rats were sacrificed, the testes were removed entirely, and the morphometric studies were carried out. Epididymal sperm count and histological studies of testicular tissue were conducted.
RESULTS:
The comparison between the treated and control groups revealed a remarkable increase in the seminiferous tubules diameter, testes volume (p=0.001), and the number of spermatogonia, primary spermatocytes and spermatozoa. Furthermore, the increase in the number of spermatids and epididymal weight were only significant at high doses of the extract (p= 0.05).
CONCLUSIONS:
The results from this study indicated that administration of celery leaf extract may improve spermatogenesis process and also be useful for some sperm fertility parameters.
KEYWORDS:
Celery; Leaves; Rat; Spermatogenesis; Spermatozoid; Testis
PMID: 25949952 PMCID: PMC4418060  Avicenna J Phytomed. 2015 Mar-Apr;5(2):113-9. ncbi.nlm.nih.gov