Rehmannia Six Liu wei di huang wan          
FUNCTIONS- Most used general Kidney tonic
GROUP: Tonify Yin
1. Nourishes the Kidney and Liver Yin, enriches the Kidney Jing.
INDICATIONS
1. Liver and Kidney Yin deficiency: pain and weakness of lower back, dizziness, tinnitus, loss of hearing, poor sleep, sensation of heat in the five centres (soles, palms and chest), dry mouth, nocturnal emission, nocturnal sweating T- red with little coating P- deep thready or thready rapid.
APPLICATIONS: Retarded growth of children, enuresis, hypertension, diabetes, chronic nephritis, urinary tract infection, lumbago, hyperthryoidism, optic neuritis, pulmonary tuberculosis, neurasthenia, uterine bleeding
INGREDIENTS
Rehmannia glutinosa- 熟地黃 Shú dì huáng- Cooked rehmannia
Cornus officinalis- 山茱萸 Shān Yū Roú Cornelian cherry
Dioscorea oppositifolia- 山药 Shān Yao- Chinese yam
Paeonia suffruticosa- 牡丹皮 Mǔ dān pí- Tree peony
Poria cocos-  茯苓 Fú líng- Hoelen wood fungus
Alisma plantago- 泽泻 Zé xiè- Water plantain tuber, Alisma
CONTRAINDICATIONS: Spleen Deficiency with bloated stomach and loose stools.

Research

Protective Effects of Liu Wei Di Huang Wan on the Liver, Orbitofrontal Cortex Nissl Bodies, and Neurites in MSG+PH-Induced Liver Regeneration Rat Model
Bin-Bin Zhao, Qing-hua Long, Chao-yang Wang, 1 Lin-lin Chen, Guang-jing Xie, Wen-ji Bo, Bo Xu, Ze-fei Li, Han-Min Li, and Ping Wang
Abstract
Introduction. To examine the protective effects of Liu Wei Di Huang Wan formula (LWDH) on liver and orbitofrontal cortex (OFC) injuries in monosodium glutamate (MSG) and partial hepatectomy (PH) rat model. Methods. Neonatal Wistar rats were given MSG or saline on postnatal days 2, 4, 6, 8, and 10. The rats were caged into five groups and treated accordingly at six weeks old as follows: Saline group, Saline+PH group, MSG group, MSG+PH group, and LWDH group (MSG+PH+LWDH). The PH was performed during week 8 by excision of the left and median hepatic lobes (occupying about 68% of whole liver).On day 8 after the PH, the rats were subjected to an inner OFT before being sacrificed. The liver and OFC were stained using H&E, ORO, or Nissl staining. The expression of neurotrophic factors (β-NGF, BDNF) was examined in the OFC lysates by ELISA. Serum levels of cytokines (IL-1β, VEGF) were examined using the Bio-Plex suspension array. Results. LWDH increased the total distance traveled by the animals (p<0.05), and LWDH improved the integrity of the Nissl bodies in the OFC (mean area of the Nissl bodies, p<0.01; mean diameter, p<0.05; mean density, p<0.05; and IOD, p<0.01). There were less white area in the liver (p>0.05) and decreased hepatic steatosis (p<0.01) in LWDH group. LWDH administration decreased the expression of serum levels of IL-1β (p>0.05), while it increased VEGF (p>0.05) expression. LWDH administration increased the expression of BDNF (p>0.05) and β-NGF (p>0.05) in the OFC, all as compared to the MSG+PH group. Conclusion. LWDH partly protected the animals from depressive-like behaviors in the MSG+PH-induced liver regeneration neonatal rat model. LWDH alleviated hepatic injury and steatosis and, furthermore, protected the Nissl body integrity and the growth of neurites.
Evid Based Complement Alternat Med. 2018; 2018: 9090128.
Published online 2018 Aug 27. doi: 10.1155/2018/9090128
PMCID: PMC6129786 PMID: 30224933 ncbi.nlm.nih.gov